The CA16003 Compute Accelerator with sixteen AMD Radeon Instinct MI25 GPU accelerators is employed in a variety of HPC applications including machine learning. Completely integrated with the GPUs most suited for a specific application, it's easy installation and tested reliability makes it superior to alternative products. The CA16003 occupies only 3U of rack space and connects directly to four host servers through the latest technology PCIe x16 Gen3 connections. Four removable canisters house up to four full-height, full-length, PCIe x16 double-wide GPUs and one half-length, half-height IO card each. The system is powered by three 3000-watt redundant power supplies and includes an IPMI-based system monitor.